NEWS...
Treatment of long-lasting facial nerve palsy: a pilot randomized controlled trial
A pilot randomized controlled trial on the combination of Guna Collagen MDs MD Neural, MD Matrix and MD Muscle plus rehabilitative treatment for preventing or reducing residual deficits in patients with established and long-term facial palsy has been published in “European Journal of Physical and Rehabilitation Medicine”.
Micarelli A. et al. Combination of in-situ collagen injection and rehabilitative treatment in long-lasting facial nerve palsy: a pilot randomized controlled trial. European Journal of Physical and Rehabilitation Medicine 15July 2020.
Published Clinical Trials & Assessments
General on Collagen MDs
Milani L. A new and refined treatment for musculo-skeletal disorders – Bioscaffold properties of collagen and its clinical use. Physiological Regulating Medicine, 2010; 3-15.
Milani L. The collagen medical devices in the local treatment of the algic arthro-rheumopathies – Review of the clinical studies and clinical assessments 2010-2012. Physiological Regulating Medicine, 2013; 21-36.
Milani L. Guna collagen medical devices 10 years on − a reasoned analysis of 2 recent important studies and literature update. Physiological Regulating Medicine, 2019-20; 3-18
Pre-clinical
Randelli F. et al. Effect of a Collagen-Based Medical Compound on Morpho-Functional Properties of Cultured Human Tenocytes”, Cells 2018 Dec 6;7(12)
Randelli F. et al. Characterization of collagen turnover in human tenocytes cultured on the collagen-based medical device MD-TISSUE. La Medicina Biologica, 2018/4; 67-68.
Randelli F. et al. The Collagen-Based Medical Device MD-Tissue Acts as a Mechanical Scaffold Influencing Morpho-Functional Properties of Cultured Human Tenocytes. Cells. 2020 Dec;9(12).
Specific on Collagen MDs use Rachis Pathologies
Zocco R. et al. Effectiveness of integrated medicine in the control of pain in vertebral disorders: Observational study. Physiological Regulating Medicine, 2012; 41.
Pavelka K. et al. MD-LUMBAR, MD-MUSCLE and MD-NEURAL in the treatment of low back pain. Physiological Regulating Medicine, 2012; 3-6.
Illich M. The success of the right dose in the right points. Poster presented at the International Congress of PRM, Prague (CZ), November 2013.
Perényi J. Efficiency of Guna MDs in therapy resistant failed back surgery syndrome. Poster presented at the International Congress of PRM, Prague (CZ), November 2013.
Gundrum B. Success story of GUNA MDs in low back pain syndrome. Poster presented at the International Congress of PRM, Prague (CZ), November 2013.
Biszku Z. Success of Guna MDs in ruptured lumbar herniated disc. Poster presented at the International Congress of PRM, Prague (CZ), November 2013.
Raychev I. Efficacy and safety of combined treatment with Guna MD – LUMBAR and Guna MD- ISCHIAL collagen injections in patients with lumbar disc herniation. Dvigatelni Narusheniya (Movement Disorders Bulgaria), 2013/2; 28- 32.
Staňa J. Three years in Luhačovice Spa with Collagen Medical Devices injections in the treatment of piriformis syndrome. Physiological Regulating Medicine, 2017; 19-20.
Pavelka K. et al. Chronic Low Back Pain: Current Pharmacotherapeutic Therapies and a New Biological Approach. Current Medicinal Chemistry, 2018.
Pavelka K. et al. Efficacy and tolerability of injectable Collagen-containing Products in comparison to Trimecaine in Patients with acute lumbar spine pain (Study FUTURE-MD-Back Pain). Physiological Research, vol.68, Suppl. 1, 2019; 65-74.
Godek P. Collagen Therapy in Lumbar Spondylosis – a Pilot Study. Does the Route of Administration Matter? Ortopedia Traumatologia Rehabilitacja, 2019; 6(6); Vol. 21, 427-434.
Milano E. Collagen Medical Device Lumbar in the combined treatment of lumbar instability-induced pain. Physiological Regulating Medicine, 2020; 39-44.
Godek P. Collagen therapy in lumbar spondylosis. Does the method of administration matter? – a pilot study. Physiological Regulating Medicine, 2020; 33-37
Specific on Collagen MDs use Knee Pathologies
Nestorova R. et al. Efficiency of collagen injections of Guna MD in patients with gonarthrosis, assessed clinically and by ultrasounds. Physiological Regulating Medicine, 2012; 37-39.
Boshnakov D. Application and assessment of efficacy of collagen injections Guna MDs in gonarthrosis. Physiological Regulating Medicine, 2013; 29-30.
Martin Martin L.S. et al. A double blind randomized active-controlled clinical trial on the intra-articular use of MD-KNEE versus sodium hyaluronate in patients with knee osteoarthritis (“Joint”). BMC Musculoskeletal Disorders, 2016; 17-94.
Mariconti P. Usefulness of Guna Collagen Medical Devices in the treatment of knee pain. Physiological Regulating Medicine, 2017; 39-40.
Reshkova V. et al. Efficacy and safety evaluation of Guna Collagen MDs injections in knee osteoarthritis – A case series of 30 patients. Physiological Regulating Medicine, 2017; 27-29.
Migliore A., Ravasio R. A cost-minimisation analysis of md-knee versus hyaluronic acid in the treatment of patients with knee osteoarthritis. AboutOpen, 2020; 7(1): 16–20.
Nguyen Vinh N. Initial assessment of effectiveness of intra-articular MD-KNEE injection therapy in treatment of primary knee osteoarthritis in Bach Mai Hospital – Hanoi, Vietnam. Physiological Regulating Medicine, 2020; 27-31.
Migliore A., Ravasio R. A cost-minimisation analysis of MD-Knee versus hyaluronic acid in the treatment of patients with knee osteoarthritis. Physiological Regulating Medicine, 2020; 3-7.
Specific on Collagen MDs use Hip Pathologies
Tivchev P. Efficacy of collagen injections Guna MD-HIP and Guna MD-MATRIX in treatment of coxarthrosis – Clinical and ultrasonographic examination. Ortopediya i Travmatologiya (Bulgarian Journal of Orthopedics and Trauma), 2012/3, vol. 49; 123-128.
Migliore A. Intra-articular administration of MD-HIP in 7 patients affected by ostheoarthritis unresponsive to viscosupplementation – six-month multicenter trial. Poster presented at the International Symposium of Intra-articular treatment (ISIAT), Rome (IT), October 2011. Physiological Regulating Medicine 2013; 31.
Giovannangeli F. Intra articular administration of MD HIP in 24 patients affected by symptomatic hip osteoarthritis – a 24-month cohort study. Physiological Regulating Medicine, 2017; 31-32.
Milano E. The role of MD-HIP In ultrasound-guided injection therapy for osteoarthritis of the hip. Physiological Regulating Medicine, 2018; 3-8.
Specific on Collagen MDs use Shoulder Pathologies
Farkas K. Efficacy of Guna MDs in muscle tears. Poster presented at International Congress of PRM, Prague (CZ), November 2013.
Nestorova R. et al. Clinical and sonographic assessment of the effectiveness of collagen injections Guna MDs in shoulder periarthrits with bursitis. Physiological Regulating Medicine, 2017; 35-37. Published on: European Journal of Musculoskeletal diseases 2014/3, n.1; 15-23.
Zurita Uroz. Collagen Medical Device infiltration in shoulder pathologies. Calcific supraspinatus tendinitis. Physiological Regulating Medicine 2017; 15-17.
Nestorova R. et al. Bulgarian experience with injectable collagen guna medical devices in shoulder periarthritis. Physiological Regulating Medicine, 2020; 9-16.
Corrado B. Use of injectable collagen in partial-thickness tears of the supraspinatus tendon: a case report. Oxford Medical Case Reports, 2020;11,408–410.
Corrado B. et al. Ultrasound-guided collagen injections in the treatment of supraspinatus tendinopathy: a case series pilot study. Advances in in musculoskeletal diseases and infections. Journal of Biological Regulators and Homeostatic Agents. 2020 May-Jun;34(3 Suppl. 2):33-39.
Specific on Collagen MDs use Elbow Pathologies
Corrado B. et. al. Treatment of Lateral Epicondylitis with Collagen Injections: a Pilot Study. Muscles, Ligaments, Tendons Journal 2019; 584-589
Hernandez Herrero D. Value of pain and satisfaction after treatment with subcutaneous collagen in patients with epicondylitis refractory to other treatments. Physiological Regulating Medicine, 2020; 19-25.
Ahumada Arredondo O. Epicondylitis − a solution with collagen medical devices. Physiological Regulating Medicine, 2020; 45-55.
Specific on Collagen MDs use Hand and Foot Pathologies
Presti C. A. Swine Collagen-Based Medical Devices with ancillary substances in the Injective Treatment of Plantar Fasciitis. Advanced Therapies, 8/2015; 46-50
Bernardini G. Rhizarthrosis and homeosiniatry, efficacy of Zeel® T vs MD-Small Joints. Physiological Regulating Medicine, 2018; 15-23.
Specific on Collagen MDs use Muscle pain
Cobos Romana R. Effects on the rates of quality of life in fibromyalgia patients treated with Collagen MDs. Clinical assessment presented at International Congress of PRM, Prague (CZ) November 2013.
Alfieri N. MD-Muscle in the management of myofascial pain syndrome. Physiological Regulating Medicine 2017; 23-24.
Nitecka-Buchta et al. Comparison between Collagen and Lidocaine Intramuscular Injections in Terms of Their Efficiency in Decreasing Myofascial Pain within Masseter Muscles: A Randomized, Single-Blind Controlled Trial. Pain Research and Management, 2018
Various on Collagen MDs use
Horvath K. Effects of Guna MDs in therapy-resistant facial paresis. Clinical assessment presented at International Congress of PRM, Prague (CZ) November 2013.
Guitart Vela Collagen MDs for chronic pain. Efficacy and olerability in chronic treatment in 124 patients. Physiological Regulating Medicine 2017; 9-12.
Ottaviani M. Treatment of joint conditions with Guna Collagen Medical Devices – Clinical study on 257 patients. Physiological Regulating Medicine, 2018; 19-28.
Micarelli A. et al. Combination of in-situ collagen injection and rehabilitative treatment in long-lasting facial nerve palsy: a pilot randomized controlled trial. European Journal of Physical and Rehabilitation Medicine 2020 Jul 15.
Combination therapies with Collagen MDs
Posabella G. Patello-Femoral Chondropathy Treated With MD-KNEE + Zeel® T Transmitted With O2 Vs Nimesulide + Chondroitin Sulphate. Physiological Regulating Medicine 2011; 3-10.
Massullo C. Injectable Guna Collagen Medical Devices in functional recovery from sport traumatology. Case reports. Physiological Regulating Medicine, 2017; 3-7.
Fennino D., Bonacina A. Collagen Medical Devices and chelt therapy in shoulder and knee osteo-articular pain La Medicina Biologica 2017/2; 37-42.
Aesthetic Medicine
Falconi Klein E. Face Revitalization – Biolifting with MD-TISSUE. Physiological Regulating Medicine 2012; 15-20.
Elenkova S., Pozharashka J. Acumesotherapy with Guna MD-MATRIX in patients with localized abdominal adiposity. Physiological Regulating Medicine, 2012; 43.
Elenkova S., Pozharashka J. Acumesotherapy with injectable collagen in patients with localized adiposity of the knees. Poster presented at the European Congress of Integrative Medicine (ECIM), Florence (IT), September 2012.
